diff --git a/Source/Core/Core/HotkeyManager.cpp b/Source/Core/Core/HotkeyManager.cpp
index 02c0191256..b7c5c161c2 100644
--- a/Source/Core/Core/HotkeyManager.cpp
+++ b/Source/Core/Core/HotkeyManager.cpp
@@ -35,6 +35,7 @@ constexpr std::array<const char*, NUM_HOTKEYS> s_hotkey_labels{{
     _trans("Take Screenshot"),
     _trans("Exit"),
     _trans("Unlock Cursor"),
+    _trans("Center Mouse"),
     _trans("Activate NetPlay Chat"),
     _trans("Control NetPlay Golf Mode"),
 
diff --git a/Source/Core/Core/HotkeyManager.h b/Source/Core/Core/HotkeyManager.h
index b214c95a66..b58f9c2828 100644
--- a/Source/Core/Core/HotkeyManager.h
+++ b/Source/Core/Core/HotkeyManager.h
@@ -29,6 +29,7 @@ enum Hotkey
   HK_SCREENSHOT,
   HK_EXIT,
   HK_UNLOCK_CURSOR,
+  HK_CENTER_MOUSE,
   HK_ACTIVATE_CHAT,
   HK_REQUEST_GOLF_CONTROL,
 
diff --git a/Source/Core/DolphinQt/HotkeyScheduler.cpp b/Source/Core/DolphinQt/HotkeyScheduler.cpp
index 52fd1ac00a..6d7c91a6ee 100644
--- a/Source/Core/DolphinQt/HotkeyScheduler.cpp
+++ b/Source/Core/DolphinQt/HotkeyScheduler.cpp
@@ -233,6 +233,9 @@ void HotkeyScheduler::Run()
       if (IsHotkey(HK_UNLOCK_CURSOR))
         emit UnlockCursor();
 
+      if (IsHotkey(HK_CENTER_MOUSE, true))
+        g_controller_interface.SetMouseCenteringRequested(true);
+
       auto& settings = Settings::Instance();
 
       // Toggle Chat
diff --git a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp
index 1c4dc71da8..442e5502fa 100644
--- a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp
+++ b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.cpp
@@ -421,6 +421,16 @@ Common::Vec2 ControllerInterface::GetWindowInputScale() const
     return {1 / ar, 1.f};
 }
 
+void ControllerInterface::SetMouseCenteringRequested(bool center)
+{
+  m_requested_mouse_centering = center;
+}
+
+bool ControllerInterface::IsMouseCenteringRequested() const
+{
+  return m_requested_mouse_centering.load();
+}
+
 // Register a callback to be called when a device is added or removed (as from the input backends'
 // hotplug thread), or when devices are refreshed
 // Returns a handle for later removing the callback.
diff --git a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h
index 2f43cacc42..3a0276de41 100644
--- a/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h
+++ b/Source/Core/InputCommon/ControllerInterface/ControllerInterface.h
@@ -106,6 +106,11 @@ public:
   // Inputs based on window coordinates should be multiplied by this.
   Common::Vec2 GetWindowInputScale() const;
 
+  // Request that the mouse cursor should be centered in the render window at the next opportunity.
+  void SetMouseCenteringRequested(bool center);
+
+  bool IsMouseCenteringRequested() const;
+
   HotplugCallbackHandle RegisterDevicesChangedCallback(std::function<void(void)> callback);
   void UnregisterDevicesChangedCallback(const HotplugCallbackHandle& handle);
   void InvokeDevicesChangedCallbacks() const;
@@ -127,6 +132,7 @@ private:
   std::atomic<int> m_populating_devices_counter;
   WindowSystemInfo m_wsi;
   std::atomic<float> m_aspect_ratio_adjustment = 1;
+  std::atomic<bool> m_requested_mouse_centering = false;
 };
 
 namespace ciface