diff --git a/Source/Core/Core/IOS/USB/Emulated/Microphone.cpp b/Source/Core/Core/IOS/USB/Emulated/Microphone.cpp
index 6d8b4740e8..e58812488d 100644
--- a/Source/Core/Core/IOS/USB/Emulated/Microphone.cpp
+++ b/Source/Core/Core/IOS/USB/Emulated/Microphone.cpp
@@ -7,7 +7,10 @@
 
 #include <cubeb/cubeb.h>
 
+#ifdef HAVE_CUBEB
 #include "AudioCommon/CubebUtils.h"
+#endif
+
 #include "Common/Logging/Log.h"
 #include "Common/MathUtil.h"
 #include "Common/Swap.h"
@@ -36,6 +39,23 @@ Microphone::~Microphone()
   StreamTerminate();
 }
 
+#ifndef HAVE_CUBEB
+void Microphone::StreamInit()
+{
+}
+
+void Microphone::StreamStart([[maybe_unused]] u32 sampling_rate)
+{
+}
+
+void Microphone::StreamStop()
+{
+}
+
+void Microphone::StreamTerminate()
+{
+}
+#else
 void Microphone::StreamInit()
 {
   if (!m_worker.Execute([this] { m_cubeb_ctx = CubebUtils::GetContext(); }))
@@ -168,6 +188,7 @@ long Microphone::DataCallback(cubeb_stream* stream, void* user_data, const void*
 
   return nframes;
 }
+#endif
 
 u16 Microphone::ReadIntoBuffer(u8* ptr, u32 size)
 {
diff --git a/Source/Core/Core/IOS/USB/Emulated/Microphone.h b/Source/Core/Core/IOS/USB/Emulated/Microphone.h
index 638448dc11..4bb8229db4 100644
--- a/Source/Core/Core/IOS/USB/Emulated/Microphone.h
+++ b/Source/Core/Core/IOS/USB/Emulated/Microphone.h
@@ -13,11 +13,14 @@
 #include <ranges>
 #include <type_traits>
 
-#include "AudioCommon/CubebUtils.h"
 #include "Common/CommonTypes.h"
 
+#ifdef HAVE_CUBEB
+#include "AudioCommon/CubebUtils.h"
+
 struct cubeb;
 struct cubeb_stream;
+#endif
 
 namespace IOS::HLE::USB
 {
@@ -40,8 +43,10 @@ public:
   void SetSamplingRate(u32 sampling_rate);
 
 private:
+#ifdef HAVE_CUBEB
   static long DataCallback(cubeb_stream* stream, void* user_data, const void* input_buffer,
                            void* output_buffer, long nframes);
+#endif
 
   void StreamInit();
   void StreamTerminate();
@@ -114,11 +119,13 @@ private:
   Loudness m_loudness;
 
   std::mutex m_ring_lock;
-  std::shared_ptr<cubeb> m_cubeb_ctx = nullptr;
-  cubeb_stream* m_cubeb_stream = nullptr;
 
   const WiiSpeakState& m_sampler;
 
+#ifdef HAVE_CUBEB
+  std::shared_ptr<cubeb> m_cubeb_ctx = nullptr;
+  cubeb_stream* m_cubeb_stream = nullptr;
   CubebUtils::CoInitSyncWorker m_worker{"Wii Speak Worker"};
+#endif
 };
 }  // namespace IOS::HLE::USB
diff --git a/Source/Core/DolphinLib.props b/Source/Core/DolphinLib.props
index e20ceb0fc9..bd68021aaf 100644
--- a/Source/Core/DolphinLib.props
+++ b/Source/Core/DolphinLib.props
@@ -1,9 +1,12 @@
 <?xml version="1.0" encoding="utf-8"?>
 <Project>
-  <ItemGroup>
-    <ClInclude Include="AudioCommon\AudioCommon.h" />
+  <ItemGroup Condition="'$(EnableCubeb)'!='false'">
     <ClInclude Include="AudioCommon\CubebStream.h" />
     <ClInclude Include="AudioCommon\CubebUtils.h" />
+    <ClInclude Include="Core\HW\EXI\EXI_DeviceMic.h" />
+  </ItemGroup>
+  <ItemGroup>
+    <ClInclude Include="AudioCommon\AudioCommon.h" />
     <ClInclude Include="AudioCommon\Enums.h" />
     <ClInclude Include="AudioCommon\Mixer.h" />
     <ClInclude Include="AudioCommon\NullSoundStream.h" />
@@ -289,7 +292,6 @@
     <ClInclude Include="Core\HW\EXI\EXI_DeviceGecko.h" />
     <ClInclude Include="Core\HW\EXI\EXI_DeviceIPL.h" />
     <ClInclude Include="Core\HW\EXI\EXI_DeviceMemoryCard.h" />
-    <ClInclude Include="Core\HW\EXI\EXI_DeviceMic.h" />
     <ClInclude Include="Core\HW\EXI\EXI_DeviceModem.h" />
     <ClInclude Include="Core\HW\EXI\EXI.h" />
     <ClInclude Include="Core\HW\GBACore.h" />
@@ -773,10 +775,13 @@
     <ClInclude Include="VideoCommon\XFStateManager.h" />
     <ClInclude Include="VideoCommon\XFStructs.h" />
   </ItemGroup>
-  <ItemGroup>
-    <ClCompile Include="AudioCommon\AudioCommon.cpp" />
+  <ItemGroup Condition="'$(EnableCubeb)'!='false'">
     <ClCompile Include="AudioCommon\CubebStream.cpp" />
     <ClCompile Include="AudioCommon\CubebUtils.cpp" />
+    <ClCompile Include="Core\HW\EXI\EXI_DeviceMic.cpp" />
+  </ItemGroup>
+  <ItemGroup>
+    <ClCompile Include="AudioCommon\AudioCommon.cpp" />
     <ClCompile Include="AudioCommon\Mixer.cpp" />
     <ClCompile Include="AudioCommon\NullSoundStream.cpp" />
     <ClCompile Include="AudioCommon\OpenALStream.cpp" />
@@ -960,7 +965,6 @@
     <ClCompile Include="Core\HW\EXI\EXI_DeviceGecko.cpp" />
     <ClCompile Include="Core\HW\EXI\EXI_DeviceIPL.cpp" />
     <ClCompile Include="Core\HW\EXI\EXI_DeviceMemoryCard.cpp" />
-    <ClCompile Include="Core\HW\EXI\EXI_DeviceMic.cpp" />
     <ClCompile Include="Core\HW\EXI\EXI_DeviceModem.cpp" />
     <ClCompile Include="Core\HW\EXI\EXI.cpp" />
     <ClCompile Include="Core\HW\GBACore.cpp" />
diff --git a/Source/Core/DolphinQt/EmulatedUSB/WiiSpeakWindow.cpp b/Source/Core/DolphinQt/EmulatedUSB/WiiSpeakWindow.cpp
index 67d8433677..f22fe93117 100644
--- a/Source/Core/DolphinQt/EmulatedUSB/WiiSpeakWindow.cpp
+++ b/Source/Core/DolphinQt/EmulatedUSB/WiiSpeakWindow.cpp
@@ -14,7 +14,9 @@
 #include <QString>
 #include <QVBoxLayout>
 
+#ifdef HAVE_CUBEB
 #include "AudioCommon/CubebUtils.h"
+#endif
 #include "Core/Config/MainSettings.h"
 #include "Core/Core.h"
 #include "Core/System.h"
@@ -93,6 +95,10 @@ void WiiSpeakWindow::CreateMainWindow()
   config_layout->setStretch(1, 3);
 
   m_combobox_microphones = new QComboBox();
+#ifndef HAVE_CUBEB
+  m_combobox_microphones->addItem(QLatin1String("(%1)").arg(tr("Audio backend unsupported")),
+                                  QString{});
+#else
   m_combobox_microphones->addItem(QLatin1String("(%1)").arg(tr("Autodetect preferred microphone")),
                                   QString{});
   for (auto& [device_id, device_name] : CubebUtils::ListInputDevices())
@@ -100,6 +106,7 @@ void WiiSpeakWindow::CreateMainWindow()
     const auto user_data = QString::fromStdString(device_id);
     m_combobox_microphones->addItem(QString::fromStdString(device_name), user_data);
   }
+#endif
   connect(m_combobox_microphones, &QComboBox::currentIndexChanged, this,
           &WiiSpeakWindow::OnInputDeviceChange);
 
diff --git a/Source/VSProps/Base.Dolphin.props b/Source/VSProps/Base.Dolphin.props
index 3410b9fef6..f2f213b009 100644
--- a/Source/VSProps/Base.Dolphin.props
+++ b/Source/VSProps/Base.Dolphin.props
@@ -3,6 +3,7 @@
   <!--This file is included by Dolphin code only-->
   <PropertyGroup>
     <TargetName Condition="'$(ConfigurationType)'=='Application'">$(ProjectName)$(TargetSuffix)</TargetName>
+    <EnableCubeb>true</EnableCubeb>
   </PropertyGroup>
   <ItemDefinitionGroup>
     <ClCompile>
@@ -47,7 +48,7 @@
       <PreprocessorDefinitions>USE_RETRO_ACHIEVEMENTS;%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <PreprocessorDefinitions>RC_CLIENT_SUPPORTS_HASH;%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <PreprocessorDefinitions>RC_CLIENT_SUPPORTS_RAINTEGRATION;%(PreprocessorDefinitions)</PreprocessorDefinitions>
-      <PreprocessorDefinitions>HAVE_CUBEB;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+      <PreprocessorDefinitions Condition="'$(EnableCubeb)'!='false'">HAVE_CUBEB;%(PreprocessorDefinitions)</PreprocessorDefinitions>
 
       <!-- Warnings one may want to ignore when using Level4.
       4201  nonstandard extension used : nameless struct/union